🩺 Nervigesic 450 mg Capsule (Pregabalin)
Generic Name: Pregabalin
Brand Name: Nervigesic 450
Manufacturer: Signature Phytochemical Industries
Form: Oral Capsule
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Regulatory Status: Prescription-only
✅ Primary Uses
Nervigesic 450 mg is used in the management of:
- Neuropathic Pain: Including diabetic neuropathy, post-herpetic neuralgia, and nerve pain due to spinal cord injury.
- Fibromyalgia: Reduces widespread chronic musculoskeletal pain and fatigue.
- Partial-Onset Seizures: Adjunctive therapy for adults with epilepsy.
- Generalized Anxiety Disorder (GAD): Helps alleviate persistent anxiety symptoms.
⚙️ How It Works
Pregabalin modulates calcium channels in the central nervous system by binding to the alpha-2-delta subunit of voltage-gated calcium channels. This reduces the release of several neurotransmitters such as glutamate, norepinephrine, and substance P—ultimately decreasing nerve excitability and providing relief from pain, anxiety, and seizures.
💊 Dosage & Administration
- Typical Initial Dose: Often started at lower doses (e.g., 75–150 mg/day) and titrated up.
- Max Dose: Not to exceed 600 mg/day. Nervigesic 450 is usually reserved for patients who have tolerated lower doses.
- Route: Oral; swallow whole with water.
- With Food: Can be taken with or without food.
- Missed Dose: If you miss a dose, take it as soon as you remember unless it’s near the time for the next dose. Do not double up.
Important: Dosage should only be adjusted under medical supervision.
⚠️ Warnings & Precautions
- Renal Impairment: Dose adjustments required for patients with compromised kidney function.
- Pregnancy & Lactation: Use only if clearly needed. Consult your doctor.
- Alcohol: May intensify sedative effects—avoid concurrent use.
- Elderly Patients: Increased risk of dizziness and falls; monitor closely.
- Mental Health: Monitor for mood changes, depression, or suicidal thoughts.
❌ Common Side Effects
- Dizziness and drowsiness
- Blurred vision
- Dry mouth
- Weight gain
- Swelling in hands or feet (peripheral edema)
- Difficulty concentrating
- Fatigue
Most side effects are mild and may diminish with continued use. Report any persistent or severe reactions to your doctor.
🔄 Drug Interactions
- CNS Depressants: May increase sedation and respiratory depression when combined with opioids, alcohol, or benzodiazepines.
- Oral Diabetes Medications (e.g., thiazolidinediones): Risk of fluid retention.
- Other Antiepileptics: May interact; consult your physician for a full medication review.
📦 Storage
- Temperature: Store between 20°C and 25°C
- Conditions: Keep in a dry place, away from direct sunlight and moisture
- Safety: Keep out of reach of children and pets
📝 Summary
Nervigesic 450 mg is a high-strength formulation of Pregabalin designed for individuals with severe, treatment-resistant neuropathic pain or advanced fibromyalgia. It provides potent symptom control but should be used cautiously due to its sedative effects and potential for dependency. Regular follow-up with a healthcare provider is essential for safety and efficacy.
