💊 Nervismart 300 mg Capsule (Pregabalin)
Generic Name: Pregabalin
Brand Name: Nervismart 300
Manufacturer: Signature Phytochemical Industries
Form: Oral Capsule
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Prescription Status: Prescription Only
✅ Indications
Nervismart 300 mg is used for the treatment of several neurological and chronic pain conditions:
- Neuropathic Pain: Associated with diabetes (diabetic neuropathy), spinal cord injury, and shingles (postherpetic neuralgia).
- Fibromyalgia: Helps relieve widespread chronic muscle pain and fatigue.
- Partial-Onset Seizures: Used as adjunct therapy for adults with epilepsy.
- Generalized Anxiety Disorder (GAD): Reduces symptoms of excessive worry and anxiety.
⚙️ Mechanism of Action
Pregabalin works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of neurotransmitters such as glutamate, norepinephrine, and substance P—helping calm overactive nerves and relieving pain, seizures, and anxiety symptoms.
💊 Dosage & Administration
- Usual Starting Dose: Typically initiated at a lower dose (e.g., 75–150 mg per day) and titrated based on response.
- Maximum Daily Dose: 600 mg per day.
- Route: Oral; swallow whole with water.
- Food: May be taken with or without food.
- Missed Dose: If a dose is missed, take it as soon as remembered. Skip if it’s near the time of the next dose—do not double up.
Always follow your physician’s instructions when adjusting dosage.
⚠️ Warnings & Precautions
- Renal Impairment: Dose adjustments may be necessary.
- Pregnancy & Lactation: Use only if clearly needed; consult a doctor.
- Elderly Patients: Greater sensitivity to side effects such as dizziness or confusion.
- Alcohol & Sedatives: May increase CNS depression—avoid use together.
- Mental Health: Monitor for mood changes or suicidal ideation.
❌ Common Side Effects
- Drowsiness or dizziness
- Blurred vision
- Weight gain
- Dry mouth
- Swelling in the limbs (edema)
- Difficulty concentrating
- Fatigue
Most side effects are mild and often improve with continued use. Seek medical advice if symptoms persist or worsen.
🔄 Drug Interactions
- CNS Depressants: Increased risk of sedation when taken with opioids, alcohol, or benzodiazepines.
- Oral Diabetes Drugs: Possible risk of fluid retention with certain medications (e.g., thiazolidinediones).
- Other Antiepileptics: Potential for interaction—monitor therapy closely.
📦 Storage Instructions
- Store at: 15°C–25°C in a cool, dry place.
- Keep Away From: Moisture, heat, and direct sunlight.
- Caution: Keep out of reach of children and pets.
📝 Summary
Nervismart 300 mg delivers high-dose Pregabalin for effective relief of severe neuropathic pain, fibromyalgia, epilepsy, and anxiety. It is potent and should be used under close medical supervision, especially in patients with renal conditions or those prone to CNS side effects.
