Artvigil 250 mg – Full Product Information
Brand Name: Artvigil 250
Generic Name: Armodafinil
Strength: 250 mg
Dosage Form: Oral tablet
Manufacturer: HAB Pharmaceuticals & Research Ltd., India
Availability: Prescription-only
Packaging: Strips of 10 tablets
✅ Overview
Artvigil 250 mg is a high-strength formulation of Armodafinil, a eugeroic (wakefulness-promoting agent) used primarily to treat excessive daytime sleepiness. As the R-enantiomer of Modafinil, Armodafinil offers a longer half-life and enhanced potency, making it ideal for individuals who require sustained mental alertness.
🩺 Indications
Artvigil 250 is used in the treatment of:
- Narcolepsy – Sudden and uncontrollable episodes of sleep during the day
- Obstructive Sleep Apnea (OSA) – To reduce residual sleepiness alongside CPAP therapy
- Shift Work Sleep Disorder (SWSD) – To promote wakefulness during non-traditional working hours
Note: While the 150 mg dosage is standard, the 250 mg strength may be considered for individuals requiring longer-lasting or stronger effects, under physician supervision.
🔬 Mechanism of Action
Armodafinil enhances wakefulness by increasing extracellular levels of dopamine in the brain, primarily through dopamine reuptake inhibition. It also affects other neurotransmitter systems, including:
- Norepinephrine
- Serotonin
- Histamine
- Orexin (hypocretin)
This multifaceted mechanism results in improved alertness, cognitive function, and resistance to fatigue.
💊 Dosage & Administration
- Standard Dose: 150–250 mg once daily
- Narcolepsy/OSA: Take in the morning
- SWSD: Take ~1 hour before work shift
- With or Without Food: Food may delay absorption slightly but does not affect efficacy
Special Considerations:
- Hepatic Impairment: Use a reduced dose
- Elderly Patients: Use the lowest effective dose, with monitoring
- Avoid Evening Use: May interfere with sleep onset
Always follow your healthcare provider’s exact dosage instructions.
⚠️ Warnings & Precautions
- Dermatological Reactions: Rare, serious rashes such as Stevens-Johnson Syndrome
- Neuropsychiatric Effects: May cause anxiety, depression, hallucinations—monitor closely in those with psychiatric history
- Cardiovascular Risks: Monitor heart rate and blood pressure, especially in patients with known heart disease
- Contraceptive Interference: Reduces the effectiveness of hormonal contraceptives—use alternative methods during and for one month after treatment
- Pregnancy & Lactation: Use only if clearly necessary. Consult a healthcare provider.
🚫 Side Effects
Common Side Effects:
- Headache
- Nausea
- Dry mouth
- Dizziness
- Insomnia
- Anxiety
Serious Side Effects:
- Allergic reactions (rash, swelling, trouble breathing)
- Mental health changes (agitation, depression, suicidal thoughts)
- Chest pain or heart palpitations
Discontinue use and seek medical help if serious symptoms occur.
🔄 Drug Interactions
Armodafinil may interact with:
- CYP3A4 Inducers/Inhibitors: May affect levels of other medications
- CYP2C19 Substrates: May increase effects of drugs like diazepam, propranolol, and phenytoin
- Cyclosporine: May reduce its effectiveness
- Oral Contraceptives: Reduced efficacy—use backup methods
Inform your doctor about all medications, including over-the-counter and herbal supplements.
🗄️ Storage
- Store at 20°C to 25°C (68°F to 77°F)
- Keep away from moisture, heat, and direct sunlight
- Keep out of reach of children
📌 Summary
Artvigil 250 mg is a powerful, long-lasting wakefulness-promoting medication suitable for patients with severe or persistent sleep-related disorders. Its potent formulation makes it ideal for extended work shifts or critical tasks requiring continuous mental clarity. While generally well tolerated, it must be used under medical supervision due to its potential side effects and interactions.
Disclaimer: This information is intended for educational purposes and should not replace medical advice. Always consult a licensed healthcare provider before starting or adjusting medication.
