Avana 100 – Comprehensive Product Information
Generic Name: Avanafil
Brand Name: Avana 100 (Generic equivalent of Stendra)
Strength: 100 mg
Dosage Form: Oral Tablet
Therapeutic Class: Phosphodiesterase type 5 (PDE5) inhibitor
Indication: Treatment of Erectile Dysfunction (ED)
🔬 Mechanism of Action
Avanafil enhances erectile function by selectively inhibiting the enzyme phosphodiesterase type 5 (PDE5). This inhibition leads to increased levels of cyclic guanosine monophosphate (cGMP), which relaxes smooth muscle and increases blood flow to the penile tissue during sexual stimulation, resulting in an erection.
💊 Dosage and Administration
- Initial dose: 100 mg taken approximately 30 minutes before anticipated sexual activity
- Maximum frequency: Once per day
- Dose adjustments: May be increased to 200 mg or reduced to 50 mg based on efficacy and tolerability
- Administration: Can be taken with or without food
Note: Sexual stimulation is required for the medication to be effective.
⏱️ Onset and Duration
- Onset of action: As fast as 15–30 minutes
- Duration of effect: Up to 6 hours
Avanafil is noted for its rapid onset, offering a shorter wait time compared to other ED treatments.
⚠️ Contraindications
Avana 100 should not be used in individuals who:
- Are taking nitrates or nitric oxide donors
- Have severe hepatic or renal impairment
- Have had a recent myocardial infarction or stroke
- Have known hypersensitivity to Avanafil or any excipients
⚠️ Warnings and Precautions
- Not intended for use in women or individuals under 18
- Use with caution in patients with:
- Cardiovascular disease
- Retinal disorders (e.g., retinitis pigmentosa)
- Anatomical deformation of the penis or predisposition to priapism
- Avoid concurrent use with alcohol or grapefruit juice
🔄 Drug Interactions
Significant interactions may occur with:
- Nitrates (risk of severe hypotension)
- Alpha-blockers (risk of blood pressure drop)
- Other PDE5 inhibitors (additive effects)
- CYP3A4 inhibitors such as ketoconazole, ritonavir, or clarithromycin (may increase avanafil levels)
🤕 Adverse Effects
Common Side Effects:
- Headache
- Flushing
- Nasal congestion
- Dizziness
Uncommon/Serious Side Effects:
- Back pain
- Visual disturbances
- Prolonged erection (priapism)
- Sudden hearing or vision loss
- Hypotension or chest pain
Seek immediate medical attention for symptoms such as prolonged erection, chest pain, or vision/hearing changes.
📦 Storage and Handling
- Store at room temperature (15°C–25°C or 59°F–77°F)
- Keep in a dry, cool place, away from moisture and direct sunlight
- Keep out of reach of children
🛡️ Regulatory Status
- Prescription-only medication
- Approved in various countries as a generic version of Stendra
✅ Summary
Avana 100 offers a fast-acting, effective option for the treatment of erectile dysfunction. It is generally well-tolerated and provides a shorter wait time compared to some alternatives. As with all prescription medications, Avana 100 should be used under medical supervision to ensure safe and effective use.
