Gabasign 300 mg Capsule
Generic Name: Gabapentin
Brand Name: Gabasign 300
Manufacturer: HAB Pharmaceuticals & Research Ltd.
Dosage Form: Oral Capsule
Strength: 300 mg
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Prescription Required: Yes
Therapeutic Uses
Gabasign 300 mg is commonly prescribed for the following conditions:
- Neuropathic Pain: Effective in treating nerve pain due to diabetes, shingles (postherpetic neuralgia), or spinal cord injury.
- Partial-Onset Seizures: Used as adjunctive therapy in adults with epilepsy.
- Fibromyalgia: Helps relieve widespread muscle pain and fatigue.
- Generalized Anxiety Disorder (Off-label): May be prescribed to reduce persistent anxiety symptoms.
Mechanism of Action
Gabapentin works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This modulates the release of excitatory neurotransmitters such as glutamate and substance P, reducing nerve excitability and alleviating pain, seizures, and anxiety.
Dosage & Administration
- Initial Dose: Often begins with 300 mg once daily, then titrated up based on patient response.
- Maintenance Dose: May range between 900–1800 mg per day, divided into two or three doses.
- Maximum Dose: Up to 3600 mg/day under medical supervision.
- Administration: Swallow whole with water; do not crush or chew.
- With or Without Food: Can be taken with or without food.
- Missed Dose: Take as soon as remembered. If near the time of the next dose, skip the missed dose—do not double up.
Note: Dosage adjustments are necessary in patients with impaired kidney function.
Precautions & Warnings
- Renal Impairment: Requires dose modification.
- Pregnancy & Lactation: Use only if clearly needed and prescribed by a healthcare provider.
- Elderly: May be more sensitive to side effects such as dizziness or sedation.
- CNS Depression: Avoid alcohol or sedatives which can enhance drowsiness and dizziness.
- Mental Health: Monitor for changes in mood or suicidal thoughts, especially early in treatment.
Potential Side Effects
Common side effects include:
- Dizziness
- Drowsiness
- Fatigue
- Peripheral edema (swelling)
- Weight gain
- Blurred vision
- Coordination issues
- Dry mouth
Most side effects are mild and tend to diminish with continued use. Notify your doctor if they persist or worsen.
Drug Interactions
- Alcohol & Sedatives: May enhance sedation.
- Antacids (Aluminum/Magnesium-based): Can reduce absorption of gabapentin—separate administration by 2 hours.
- Other Antiepileptic Drugs: Monitor for possible drug interactions and additive CNS effects.
Storage Instructions
- Temperature: Store at 15°C–25°C (room temperature).
- Storage Conditions: Keep in a dry place, away from moisture and heat.
- Safety: Keep out of reach of children and pets.
Summary
Gabasign 300 mg is a well-established treatment for various types of nerve pain and seizures. Its efficacy and tolerability make it a preferred option for long-term management under medical guidance. Dosage should always be personalized and adjusted based on response and renal function.
