💊 Gabasign 400 mg Capsules
Generic Name: Gabapentin
Brand Name: Gabasign 400
Manufacturer: HAB Pharmaceuticals & Research Ltd.
Dosage Form: Oral Capsule
Strength: 400 mg
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Prescription Status: Prescription Required
✅ Indications & Uses
Gabasign 400 mg is used in the management of:
- Neuropathic Pain: Due to conditions like diabetic neuropathy, postherpetic neuralgia, and spinal cord injuries.
- Partial-Onset Seizures: As adjunctive therapy for patients with epilepsy.
- Fibromyalgia: For relief of chronic widespread muscle pain and fatigue.
- Generalized Anxiety Disorder (Off-label): May be used to manage persistent anxiety symptoms.
⚙️ Mechanism of Action
Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters (like glutamate and substance P), resulting in decreased neuronal excitability, effective pain relief, and seizure control.
💊 Dosage & Administration
- Starting Dose: Typically initiated at 300 mg/day and titrated as needed.
- Therapeutic Range: 900–1800 mg/day, divided into two or three doses.
- Maximum Dose: Up to 3600 mg/day under medical supervision.
- Administration: Swallow capsules whole with water. Do not chew or crush.
- With or Without Food: Can be taken regardless of meals.
- Missed Dose: Take it as soon as possible. Skip if it’s close to the next dose—never double up.
Note: Dose adjustments are necessary for individuals with impaired renal function.
⚠️ Precautions
- Renal Impairment: Requires careful dose adjustment based on kidney function.
- Elderly Patients: May be more sensitive to dizziness and drowsiness.
- Mental Health: Monitor for mood changes or signs of depression.
- Alcohol & CNS Depressants: Use cautiously—may enhance sedative effects.
- Pregnancy & Breastfeeding: Use only if clearly prescribed; safety data is limited.
❌ Possible Side Effects
Common Side Effects:
- Dizziness or lightheadedness
- Drowsiness or fatigue
- Peripheral edema (swelling in limbs)
- Blurred vision
- Weight gain
- Coordination issues
- Dry mouth
Side effects are generally mild and diminish over time. Report persistent or severe reactions to your healthcare provider.
🔄 Drug Interactions
- Alcohol, Opioids, and Sedatives: May increase the risk of sedation and dizziness.
- Antacids (containing aluminum/magnesium): May reduce gabapentin absorption—take gabapentin at least 2 hours after antacids.
- Other Antiepileptic Drugs: May require dosage monitoring for combined effects.
📦 Storage Instructions
- Storage Temperature: Store at 15°C–25°C (59°F–77°F).
- Environment: Keep in a cool, dry place away from moisture and sunlight.
- Keep Out of Reach of Children and Pets.
📝 Summary
Gabasign 400 mg is a trusted treatment for nerve-related pain and seizure disorders. It provides targeted symptom relief with a generally favorable safety profile. Always follow your healthcare provider’s instructions for dosing and monitoring.
