💊 Gabasign 600 mg Tablet
(Gabapentin 600 mg)
Generic Name: Gabapentin
Brand Name: Gabasign 600
Manufacturer: HAB Pharmaceuticals & Research Ltd.
Form: Oral Tablet
Strength: 600 mg
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Prescription Required: Yes
✅ Indications
Gabasign 600 mg is commonly prescribed for the treatment of:
- Neuropathic Pain: Including diabetic neuropathy, postherpetic neuralgia (shingles), and spinal cord injury-related nerve pain.
- Partial-Onset Seizures: As adjunctive therapy in adults with epilepsy.
- Fibromyalgia: To manage widespread chronic muscle pain and tenderness.
- Generalized Anxiety Disorder (off-label use): May be prescribed for the management of persistent anxiety symptoms.
⚙️ Mechanism of Action
Gabapentin acts by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters like glutamate and substance P, decreasing nerve excitability and leading to effective relief from pain, seizures, and anxiety.
💊 Dosage & Administration
- Initial Dose: Usually starts at 300 mg and is gradually increased.
- Maintenance Dose: Typically ranges from 900–1800 mg per day, in divided doses.
- Maximum Dose: Up to 3600 mg per day under close medical supervision.
- Administration: Swallow tablet whole with water; do not crush or chew.
- With or Without Food: May be taken with or without meals.
- Missed Dose: If a dose is missed, take it as soon as remembered unless it’s near the time of your next dose. Do not double the dose.
Note: Dosage adjustments are necessary in patients with kidney impairment.
⚠️ Precautions
- Renal Impairment: Requires dose modification based on kidney function.
- Elderly Patients: May be more prone to dizziness, drowsiness, or confusion.
- Alcohol & Sedatives: Avoid concurrent use as it may increase sedative effects.
- Pregnancy & Breastfeeding: Use only if clearly prescribed; consult your healthcare provider.
- Mental Health Monitoring: Monitor for behavioral changes, depression, or suicidal thoughts.
❌ Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Swelling of hands or feet (peripheral edema)
- Weight gain
- Blurred vision
- Unsteady coordination
- Dry mouth
Most side effects are mild and decrease over time. Notify your doctor if any symptoms are severe or persistent.
🔄 Drug Interactions
- Alcohol & CNS Depressants: May intensify drowsiness or dizziness.
- Antacids (e.g., aluminum/magnesium): Can reduce gabapentin absorption; take gabapentin at least 2 hours after antacids.
- Other Antiepileptics: Monitor closely for additive effects or dosage adjustments.
📦 Storage Instructions
- Temperature: Store at 15°C–25°C (59°F–77°F).
- Environment: Keep dry and protect from moisture, heat, and direct sunlight.
- Safety: Store out of reach of children and pets.
📝 Summary
Gabasign 600 mg is a well-established and effective medication for managing chronic nerve pain, seizures, and certain anxiety-related disorders. It is typically well tolerated, but should be used under medical supervision with proper dose adjustments, especially in patients with renal concerns.
