💊 Gabasign 800 mg Tablet
Active Ingredient: Gabapentin 800 mg
Brand Name: Gabasign 800
Manufacturer: HAB Pharmaceuticals & Research Ltd.
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Dosage Form: Oral Tablet
Prescription Required: Yes
✅ Indications
Gabasign 800 mg is primarily prescribed for:
- Neuropathic Pain – Relief from nerve-related pain conditions such as:
- Diabetic neuropathy
- Postherpetic neuralgia (shingles-related pain)
- Pain from spinal cord injuries
- Partial-Onset Seizures – As adjunct therapy in adults with epilepsy.
- Fibromyalgia – To alleviate chronic musculoskeletal pain.
- Generalized Anxiety Disorder (off-label) – May be used to manage persistent anxiety symptoms.
⚙️ Mechanism of Action
Gabapentin, the active compound, binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters like glutamate and substance P, resulting in diminished nerve excitability—providing pain relief, seizure control, and mood stabilization.
💊 Dosage & Administration
- Initial Dose: Generally begins at 300 mg/day, titrated upward based on patient response.
- Maintenance Dose: Typically ranges from 900 to 1800 mg/day, divided into 2 or 3 doses.
- Maximum Dose: May be increased up to 3600 mg/day if clinically justified.
- Administration: Swallow the tablet whole with water. Do not crush or chew.
- Food: Can be taken with or without food.
- Missed Dose: Take as soon as remembered. Skip if it’s close to the next scheduled dose. Do not double-dose.
Note: Dosage adjustments are essential in patients with renal impairment.
⚠️ Precautions & Warnings
- Renal Impairment: Requires dose modification; monitor kidney function regularly.
- Elderly Patients: Higher risk of sedation, dizziness, and coordination issues.
- Alcohol & CNS Depressants: May enhance sedative effects—use cautiously.
- Mental Health Monitoring: Watch for mood swings, depression, or suicidal ideation.
- Pregnancy & Lactation: Use only if clearly indicated and prescribed by a physician.
❌ Possible Side Effects
Common Side Effects:
- Drowsiness
- Dizziness
- Fatigue
- Swelling in hands/feet (peripheral edema)
- Weight gain
- Blurred vision
- Tremors or coordination issues
- Dry mouth
Most side effects are mild and decrease over time. Seek medical attention for persistent or severe symptoms.
🔄 Drug Interactions
- Antacids (e.g., magnesium/aluminum-based): Can reduce gabapentin absorption—administer at least 2 hours apart.
- Alcohol & Sedatives: May increase drowsiness and dizziness.
- Other Antiepileptic Drugs: Monitor closely when used concurrently.
📦 Storage Information
- Storage Conditions: Keep at 15°C to 25°C (59°F to 77°F), away from moisture and heat.
- Shelf Life: Refer to packaging for expiry.
- Safety: Store in a secure location, out of reach of children and pets.
📝 Summary
Gabasign 800 mg is a potent, prescription-strength gabapentin formulation, effective in managing various neuropathic conditions and seizure disorders. It is typically well-tolerated, especially when doses are adjusted gradually. Patients should use this medication strictly under medical supervision, especially those with kidney conditions or taking other central nervous system agents.
