Modalert 100

Modalert 100

Modalert 100 – Modafinil 100mg from the Fastest Delivery Provider. We ship Generic Provigil manufactured by Sun Pharmaceutical Industries Ltd.

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General Overview

Modalert 100 mg is a pharmaceutical-grade medication containing modafinil, a central nervous system (CNS) stimulant classified as a wakefulness-promoting agent (eugeroic). Manufactured primarily by Sun Pharmaceutical Industries, Modalert is widely used to treat excessive daytime sleepiness and is a popular alternative to branded Provigil.

Product Details

  • Brand Name: Modalert 100
  • Generic Name: Modafinil
  • Strength: 100 mg per tablet
  • Form: Oral tablet
  • Manufacturer: Sun Pharma (India)
  • Prescription Status: Prescription-only (Rx)

Therapeutic Class

  • Class: Eugeroic (Wakefulness-Promoting Agent)
  • Schedule: Schedule IV controlled substance in the U.S.

Indications (Uses)

Modalert 100 is FDA-approved for:

  1. Narcolepsy
    – To reduce excessive daytime sleepiness associated with the condition.
  2. Obstructive Sleep Apnea (OSA)
    – As an adjunct to CPAP therapy to alleviate residual sleepiness.
  3. Shift Work Sleep Disorder (SWSD)
    – To promote alertness in individuals working non-traditional hours.

Off-label uses (consult a physician before use):

  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Chronic fatigue syndrome
  • Depression-related fatigue
  • Cognitive enhancement / nootropic purposes

Mechanism of Action

While the exact mechanism is not fully understood, modafinil is known to:

  • Inhibit dopamine reuptake by binding to the dopamine transporter (DAT)
  • Increase levels of norepinephrine, serotonin, histamine, and orexin
  • Promote wakefulness without the typical side effects of amphetamine-based stimulants (e.g., jitteriness or rebound crash)

Dosage & Administration

Standard adult dosing:

  • Narcolepsy/OSA: 100–200 mg once daily in the morning
  • SWSD: 100–200 mg taken 1 hour before the start of the work shift

Administration guidelines:

  • Swallow tablet whole with water
  • Can be taken with or without food
  • Do not exceed 400 mg/day

Pharmacokinetics

  • Bioavailability: ~80% (high)
  • Onset of Action: 30–60 minutes
  • Peak Plasma Levels: 2–4 hours post-dose
  • Half-life: 12–15 hours
  • Metabolism: Primarily in the liver (CYP3A4 pathway)
  • Excretion: Mainly via the kidneys

Side Effects

Common side effects:

  • Headache (most reported)
  • Nausea
  • Nervousness or anxiety
  • Dry mouth
  • Insomnia
  • Dizziness

Less common but serious effects:

  • Skin rashes (including Stevens-Johnson Syndrome)
  • Chest pain
  • Irregular heartbeat
  • Hypertension
  • Depression or mood swings
  • Suicidal ideation (rare)

Warnings & Precautions

  • Not recommended for patients with a history of cardiovascular conditions, psychiatric disorders, or liver impairment unless under close supervision.
  • May impair judgment or motor skills during initial use.
  • Reduces the effectiveness of hormonal contraceptives for up to 1 month after use – consider alternate birth control.
  • Should not be used with alcohol or other CNS stimulants.

Drug Interactions

  • Reduces efficacy of: Birth control pills (estrogen-based), some antivirals, anticonvulsants
  • Increased risk of side effects with: SSRIs, tricyclic antidepressants, MAO inhibitors, anticoagulants (e.g., warfarin), CNS stimulants
  • Modulates CYP450 enzymes, especially CYP3A4, CYP2C19, and CYP2C9

Contraindications

  • Known hypersensitivity to modafinil or armodafinil
  • History of serious rash or allergic reactions to stimulants
  • Uncontrolled high blood pressure
  • Severe heart arrhythmias

Pregnancy & Lactation

  • Pregnancy Category C – Use only if the potential benefit justifies the risk
  • Not recommended during breastfeeding, as it’s unclear whether modafinil is excreted in breast milk

Storage Conditions

  • Store at 20°C to 25°C (68°F to 77°F)
  • Keep in a dry, cool place away from direct sunlight
  • Keep out of reach of children

Legal and Regulatory Status

  • U.S. DEA Schedule IV – Low potential for abuse and dependence
  • Banned or restricted in some countries without prescription (e.g., UAE, Japan)
  • Use responsibly and in accordance with local laws

Market Comparison

Brand Name Active Ingredient Strength Manufacturer Notes
Modalert Modafinil 100/200 mg Sun Pharma Generic, widely trusted
Provigil Modafinil 100/200 mg Cephalon (Teva) Original brand
Waklert Armodafinil 150 mg Sun Pharma Longer half-life, R-enantiomer
Modvigil Modafinil 100/200 mg HAB Pharma More cost-effective, slightly milder effect

 

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