🩺 Nervigesic 300 mg Capsule (Pregabalin)
Generic Name: Pregabalin
Brand Name: Nervigesic 300
Manufacturer: Signature Phytochemical Industries
Formulation: Oral Capsule
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Prescription Status: Prescription-only
✅ Indications
Nervigesic 300 mg is indicated for the treatment of:
- Neuropathic Pain: Effective for conditions like diabetic neuropathy, post-herpetic neuralgia (nerve pain following shingles), and pain due to spinal cord injury.
- Fibromyalgia: Provides relief from widespread musculoskeletal pain and tenderness.
- Epilepsy: Used as an adjunct therapy for partial-onset seizures.
- Generalized Anxiety Disorder (GAD): Alleviates anxiety symptoms in adults.
⚙️ Mechanism of Action
Pregabalin, the active ingredient, binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of excitatory neurotransmitters, which helps decrease nerve excitability, providing pain relief, reducing anxiety, and controlling seizures.
💊 Dosage & Administration
- Initial Dose: Typically, 75 mg twice daily or 50 mg three times daily, depending on the condition being treated.
- Maintenance Dose: Can be adjusted by your healthcare provider based on individual response and tolerability, up to a maximum dose of 600 mg per day.
- Administration: Swallow the capsule whole with a glass of water. Do not chew, crush, or split the capsule.
- Food: Can be taken with or without food.
- Missed Dose: If a dose is missed, take it as soon as you remember, unless it’s close to the time for your next dose. Do not double the dose to make up for a missed one.
⚠️ Warnings & Precautions
- Pregnancy & Breastfeeding: Consult your doctor before using during pregnancy or breastfeeding.
- Alcohol: Avoid alcohol consumption as it may increase side effects such as dizziness and drowsiness.
- Kidney Function: Dose adjustments may be necessary for individuals with impaired kidney function.
- Elderly: Older adults may require adjusted dosing due to age-related decline in kidney function.
- Allergic Reactions: Discontinue use and seek immediate medical attention if severe allergic reactions (e.g., swelling, difficulty breathing) occur.
❌ Common Side Effects
- Dizziness
- Drowsiness or fatigue
- Dry mouth
- Constipation
- Weight gain
- Edema (swelling)
- Blurred vision
Most side effects are temporary and tend to resolve with continued use. If any persist or worsen, consult your healthcare provider.
🔄 Drug Interactions
- CNS Depressants: Avoid combining with other central nervous system depressants (e.g., opioids, benzodiazepines), as it may enhance sedation and respiratory depression.
- Thiazolidinediones: Used in diabetes management, may increase weight gain and fluid retention when taken with pregabalin.
- GABA Antagonists: May reduce the effectiveness of pregabalin.
Always inform your healthcare provider about any other medications you are taking to avoid potential interactions.
📦 Storage Instructions
- Temperature: Store at room temperature (20°C to 25°C).
- Conditions: Keep in a cool, dry place, away from moisture, heat, and direct sunlight.
- Safety: Keep out of reach of children.
📝 Key Takeaway
Nervigesic 300 mg is an effective treatment for neuropathic pain, fibromyalgia, partial-onset seizures, and generalized anxiety disorder. It works by reducing nerve excitability, providing pain relief, and controlling anxiety and seizures. Always follow your healthcare provider’s instructions for safe and effective use.
