🧠 Nervisign 300 mg Capsule (Pregabalin)
Generic Name: Pregabalin
Brand Name: Nervisign 300
Manufacturer: Signature Phytochemical Industries
Dosage Form: Oral Capsule
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Prescription Required: Yes
✅ Indications
Nervisign 300 mg is used for managing a range of neurological and pain-related conditions, including:
- Neuropathic Pain: Associated with diabetes (diabetic neuropathy), post-herpetic neuralgia, and spinal cord injury.
- Fibromyalgia: Eases chronic musculoskeletal pain and associated symptoms like fatigue and sleep issues.
- Partial-Onset Seizures: Used as adjunctive therapy in adults with epilepsy.
- Generalized Anxiety Disorder (GAD): Helps reduce excessive anxiety in adults.
⚙️ Mechanism of Action
Pregabalin works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of neurotransmitters like glutamate, norepinephrine, and substance P, which play key roles in the transmission of pain, anxiety, and seizure activity. The result is a calming effect on overactive nerves.
💊 Dosage & Administration
- Recommended Use: Take as directed by your physician. Typically, the starting dose is lower (75–150 mg/day) and gradually increased based on tolerance and effectiveness.
- Maximum Daily Dose: Should not exceed 600 mg per day.
- Administration: Swallow capsule whole with water. Do not crush or chew.
- With or Without Food: Can be taken with meals or on an empty stomach.
- Missed Dose: If missed, take it as soon as you remember. Skip it if it’s almost time for the next dose. Never double-dose.
⚠️ Precautions
- Renal Impairment: Dose adjustment required; monitor kidney function.
- Pregnancy & Breastfeeding: Use only if clearly necessary. Discuss risks with your doctor.
- Elderly Population: Caution due to higher sensitivity and potential for dizziness or falls.
- Alcohol Consumption: Avoid, as it may intensify sedative effects.
- Mental Health Monitoring: Observe for signs of depression, suicidal thoughts, or behavioral changes.
❌ Common Side Effects
- Dizziness
- Drowsiness or fatigue
- Blurred vision
- Dry mouth
- Weight gain
- Swelling in hands or feet (peripheral edema)
- Difficulty concentrating
Side effects are often temporary and may lessen over time. Contact your healthcare provider if they persist or become bothersome.
🔄 Drug Interactions
- CNS Depressants: Increased sedative effect when combined with opioids, alcohol, or benzodiazepines.
- Diabetes Medications (e.g., thiazolidinediones): May increase fluid retention.
- Other Anticonvulsants: Monitor for additive effects or interactions.
📦 Storage Guidelines
- Storage Temperature: Store between 15°C–25°C.
- Environment: Keep away from moisture, heat, and direct sunlight.
- Safety: Store in a secure place out of reach of children and pets.
📝 Conclusion
Nervisign 300 mg is a high-strength Pregabalin capsule designed for patients with severe nerve pain, chronic fibromyalgia, epilepsy, or generalized anxiety. It provides potent symptom relief when used under medical supervision. Regular monitoring is essential to ensure safety, especially at higher doses.
