💊 Nervismart 450 mg Capsule (Pregabalin 450 mg)
Generic Name: Pregabalin
Brand Name: Nervismart 450
Manufacturer: Healing Pharma India Pvt. Ltd.
Form: Oral Capsule
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Prescription Required: Yes
✅ Therapeutic Uses
Nervismart 450 mg is used in the management of:
- Neuropathic Pain: Commonly associated with diabetic neuropathy, shingles (postherpetic neuralgia), and spinal cord injury.
- Fibromyalgia: Helps relieve chronic widespread muscle pain and associated fatigue.
- Partial-Onset Seizures: Used as adjunctive therapy in adults with epilepsy.
- Generalized Anxiety Disorder (GAD): Reduces persistent anxiety symptoms in adults.
⚙️ Mechanism of Action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action inhibits the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P—resulting in reduced nerve excitability and effective control of pain, seizures, and anxiety.
💊 Dosage & Administration
- Typical Starting Dose: Lower doses (e.g., 75–150 mg/day) are usually initiated and gradually increased.
- Maximum Recommended Dose: 600 mg/day
- Route: Oral – swallow the capsule whole with water.
- With or Without Food: May be taken on an empty stomach or with meals.
- Missed Dose: If a dose is missed, take it as soon as possible. Skip if it’s close to the next dose. Do not double up.
Note: Always follow your healthcare provider’s instructions. Dose adjustments may be required in patients with renal impairment.
⚠️ Precautions
- Kidney Function: Dose adjustment needed in renal impairment.
- Pregnancy & Lactation: Use only if clearly indicated. Consult your physician.
- Geriatric Use: Older adults may be more susceptible to dizziness and sedation.
- CNS Depression: Avoid alcohol and sedatives; may increase drowsiness or coordination issues.
- Mental Health Monitoring: Monitor for signs of mood changes or suicidal thoughts.
❌ Potential Side Effects
- Dizziness or drowsiness
- Fatigue
- Blurred vision
- Dry mouth
- Peripheral edema (swelling of hands or feet)
- Difficulty concentrating
- Weight gain
Most side effects are mild to moderate and diminish with continued use. Report persistent or severe reactions to your doctor.
🔄 Drug Interactions
- CNS Depressants: Enhanced sedation with opioids, alcohol, or benzodiazepines.
- Antidiabetic Agents (e.g., pioglitazone): May increase the risk of fluid retention.
- Other Anticonvulsants: May interact—monitor therapy closely.
💰 Availability & Packaging
- Pack Size: Strip of 15 capsules
- Estimated Price Range: Varies by location and pharmacy
- Prescription Status: Rx-only; dispensed via licensed medical professionals
📦 Storage Instructions
- Store at 15°C–25°C (room temperature)
- Keep in a dry, cool place away from direct light and moisture
- Keep out of reach of children and pets
📝 Summary
Nervismart 450 mg is a high-potency Pregabalin formulation designed for patients with severe neuropathic pain, chronic anxiety, epilepsy, or fibromyalgia. Due to its strength, it should be prescribed and monitored by a healthcare professional to minimize risks and ensure optimal therapeutic benefit.
