💊 Pregagesic 300 mg Capsule
(Pregabalin 300 mg)
Brand Name: Pregagesic 300
Generic Name: Pregabalin
Manufacturer: Angel Pharmaceuticals
Dosage Form: Oral Capsule
Drug Class: Anticonvulsant / Neuropathic Pain Agent
Prescription Required: Yes
✅ Indications
Pregagesic 300 mg is prescribed for:
- Neuropathic Pain: Including diabetic neuropathy, postherpetic neuralgia (shingles-related pain), and nerve pain from spinal cord injury.
- Fibromyalgia: To relieve chronic muscle pain and fatigue.
- Partial-Onset Seizures: Used as adjunctive therapy in adults with epilepsy.
- Generalized Anxiety Disorder (GAD): To manage excessive anxiety in adults.
⚙️ Mechanism of Action
Pregabalin, the active ingredient in Pregagesic 300 mg, binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of excitatory neurotransmitters, including glutamate, norepinephrine, and substance P, which decreases nerve excitability. This leads to effective pain relief, seizure control, and reduced anxiety symptoms.
💊 Dosage & Administration
- Starting Dose: Typically, treatment begins with 75–150 mg per day, which can be increased based on individual response.
- Maximum Dose: Up to 600 mg/day in divided doses.
- Administration: Take the capsule whole with water. Do not crush or chew.
- With or Without Food: Can be taken regardless of food intake.
- Missed Dose: If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose. Do not double up.
Note: Adjust dosage for patients with renal impairment, as directed by a healthcare provider.
⚠️ Precautions & Warnings
- Renal Impairment: Dose adjustments are necessary for individuals with kidney problems.
- Pregnancy & Breastfeeding: Use only if the benefits outweigh the risks. Consult your healthcare provider.
- Elderly Patients: Be cautious, as older adults may experience increased sensitivity to the medication, such as dizziness or confusion.
- Alcohol & CNS Depressants: Avoid alcohol and other sedatives as they can increase the sedative effects of this medication.
- Mental Health Monitoring: Monitor for signs of depression, mood changes, or suicidal thoughts, especially when initiating treatment.
❌ Common Side Effects
- Dizziness
- Drowsiness
- Blurred vision
- Dry mouth
- Weight gain
- Swelling of the hands or feet (peripheral edema)
- Difficulty concentrating
Side effects are usually mild and may subside over time. Contact your healthcare provider if any side effects become bothersome or persistent.
🔄 Drug Interactions
- CNS Depressants: Use with caution when combined with opioids, alcohol, or benzodiazepines, as they may enhance sedative effects.
- Diabetes Medications (e.g., thiazolidinediones): May increase fluid retention.
- Other Anticonvulsants: Monitor for potential interactions with other seizure medications.
📦 Storage Instructions
- Storage Temperature: Store at room temperature (15°C–25°C).
- Environment: Keep away from moisture, heat, and direct sunlight.
- Safety: Store out of reach of children and pets.
📝 Conclusion
Pregagesic 300 mg offers effective treatment for neuropathic pain, fibromyalgia, epilepsy, and generalized anxiety disorder. It should be taken under the supervision of a healthcare professional to ensure appropriate dosing and minimize potential side effects. Regular follow-ups are essential for optimal therapeutic outcomes.
