Vigore 50

Vigore 50

Vigore 50 – Sildenafil Citrate 100mg from the Fastest Delivery Provider. We ship Generic Viagra manufactured by German Remedies Ltd.

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Vigore 50 Red Tablet – Product Information

Generic Name: Sildenafil Citrate
Brand Name: Vigore 50 Red Tablet
Manufacturer: Cadila Healthcare Ltd (Zydus)
Formulation: Oral Tablet
Strength: 50 mg
Prescription Required: Yes

Therapeutic Indication

Vigore 50 is indicated for the treatment of erectile dysfunction (ED) in adult men, a condition characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance.

Mechanism of Action

Sildenafil, the active ingredient, is a phosphodiesterase type 5 (PDE5) inhibitor. It enhances erectile function by increasing blood flow to the penis during sexual stimulation. This is achieved through the inhibition of PDE5, an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. The accumulation of cGMP leads to smooth muscle relaxation and vasodilation.

Dosage and Administration

  • Recommended Dose: 50 mg, taken approximately one hour before sexual activity.
  • Maximum Frequency: Do not exceed one dose in 24 hours.
  • Administration: Oral, with water. Can be taken with or without food. High-fat meals may delay the onset of action.

Pharmacokinetics

  • Onset of Action: 30–60 minutes
  • Duration of Effect: 4–6 hours
  • Metabolism: Primarily hepatic via CYP3A4
  • Elimination Half-life: Approximately 4 hours

Contraindications

  • Concurrent use of nitrate-based medications (e.g., nitroglycerin)
  • Severe cardiovascular disorders
  • Known hypersensitivity to sildenafil or any excipients
  • Severe hepatic impairment or hypotension (BP <90/50 mmHg)
  • Recent history of stroke or myocardial infarction

Warnings and Precautions

  • Cardiovascular Risk: Use with caution in patients with underlying heart conditions.
  • Alcohol: May exacerbate hypotension and increase side effects.
  • Visual Impairment: Rare reports of non-arteritic anterior ischemic optic neuropathy (NAION).
  • Priapism: Seek immediate medical attention if erection lasts >4 hours.

Adverse Effects

Common:

  • Headache
  • Flushing
  • Dyspepsia
  • Nasal congestion
  • Dizziness
  • Visual disturbances (e.g., blurred vision, color tinge)

Uncommon/Rare (but serious):

  • Priapism
  • Sudden hearing loss
  • Chest pain
  • Severe allergic reactions

Drug Interactions

  • Contraindicated: Nitrates, nitric oxide donors
  • Caution with: Alpha-blockers, antihypertensives, CYP3A4 inhibitors (e.g., ketoconazole, erythromycin), CYP3A4 inducers (e.g., rifampin)

Use in Specific Populations

  • Pregnancy/Lactation: Not indicated for use in women
  • Pediatrics: Not approved for individuals under 18
  • Elderly: May require dose adjustments due to comorbidities
  • Hepatic/Renal Impairment: Use with caution; consult a physician

Availability and Pricing

  • Pack Size: Strip of 4 tablets
  • MRP (India): ₹77.70
  • Availability: Widely available across Indian pharmacies and online platforms (e.g., Netmeds, 1mg, Apollo Pharmacy)
  • Location-specific Note (Mumbai): Easily accessible via local and online pharmacies

Patient Guidance

  • Vigore 50 will not cause an erection in the absence of sexual stimulation.
  • Do not combine with other ED treatments unless advised by a physician.
  • If side effects are severe or persistent, discontinue use and seek medical attention.

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